Broad spectrum antibiotic for infection by Rickettsia, sexually transmitted disease, Respiratory tract infection, specific bacterial infections etc.

In Adults usual dosage is 200 mg on first day in one or two infusions, subsequently as per disease severity 100/200 mg daily. In Syphilis dosage can be 300 mg daily for 10 days. Infusion should be for 1-4 hours. In Paediatric patients weighing >45kg adult dose can be used. In paediatric patients weighing < 45kg and greater than 8 years of age dose of 2.2mg/kg of body weight can be administered every 12 hours.

 Doxycycline is contraindicated when hypersensitivity to any of the Tetracycline’s. Drug interactions: Anticoagulant, co-administration of Tetracyclines with penicillin, Antacid, OC pills, Antiepileptic’s etc. 

During tooth development (last half of pregnancy, infancy and childhood to the age of8 years) may cause permanent discoloration of the teeth (yellow-gray-brown). Evaluate for Clostridium difficile- associated diarrhoea. Limit sun exposure. Overgrowth of non-susceptible organisms, including fungi & superinfection.

 In patients receiving tetracyclines include anorexia, nausea, vomiting, diarrhoea, rash, photosensitivity, urticaria, and hemolyticanemia.

Pregnancy Category D. Tetracyclines are excreted in human milk; Doxycycline use during nursing should be avoided if possible. Further information available upon request.